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elastic tape; remove pads aft~r 24 hours, wipe clean, and score then and after an additional 48 hours using Draize technique .Primary dermal irritation index = 0.6, Slightly Irritating ~Protocol: New Zealand White Rabbits, 4 male, 4 female, 2-3 kg; apply 5 glkg to an area approximately 30% of the total body surface, abraded and nonabraded in 2 of each sex; cover with gal!.~e bandage, plastic wrap, and elastic tape. Remove covers after 24 hours wipe clean and observe for 14 days then sacrifice for gross necropsy.Results: No deaths at 5 glkg.QralP rotocol: 5 male,S female Sprague-Dawley rats; age approx 9 wks; oral gavage dose 5.0 glkg body weight; observation for 14 days, sacrifice and gross necropsy; if mortality less than 2 terminate study, if 2 or greater, expose other groups to determine LD50.Results: No deaths at 5 glkg.~Sensitization Protocol: 10 male Hartley guinea pigs; age approx 9-10 wks; N =10; 1.0 mL undiluted on an adhesive pad applied for 6 hr, 3 times weekly for 3 wks, challenge dose 2 wks later. Sites scored for edema and erythema at 24 hr after application; Draize tE!Chnique 1.Results: No difference between sensitizing and challenge dose effects.