Enantioselective syntheses
Enantioselective syntheses O 0031Jacobsen-Type Enantioselective Hydrolysis of Aryl Glycidyl Ethers. 31 P NMR Analysis of the Enantiomeric Composition of Oxiranes. -Efficient kinetic resolution of racemic aryl glycidyl ethers (I) is achieved by enantioselective partial hydrolysis in the presence of chiral Co III (salen) catalyst. Chiral diols (IIb) and (IIc) thus obtained are used for the efficient preparation of the β-adrenoblocking agents (S)-toliprolol (Vb) and (S)-moprolol (Vc), respectively. -(BREDIKHIN*, A. A.; STRUNSKAYA, E. I.; NOVIKOVA, V. G.; AZANCHEEV, N. M.; SHARAFUTDINOVA, D. R.; BREDIKHINA, Z. A.; Russ.
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