Synthesis of macrocylic enones starting from alkyl ether and triazole as a linker was achieved using click reaction and intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar cycloaddition. The dipoles generated from hydrazine hydrochloride, hydroxylamine and guanidine hydrochloride were reacted with macrocyclic enone to give a new class of spiro aminopyrimidines, phenyl pyrazoles and isoxazoles grafted macrocycles in good yield. The structures of newly synthesized compounds were confirmed with IR, NMR and mass spectroscopy and evaluated for their anti cancer activity.

Isoxazole derivatives R 0240Microwave Assisted Rapid and Efficient Synthesis of 2,1-Benzoisoxazoles. -An extremely fast and high yielding protocol for the synthesis of the title compounds (IV) (13 examples) is developed. The microwave irradiation is compared to the conventional method. -(RAJANARENDAR*, E.; RAO, E. K.; KARUNAKAR, D.; Indian J.

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