Peptic ulcer disease is a chronic disease of the gastrointestinal tract, mainly manifesting itself in the formation of the fairly persistent ulcer defect of the mucous membrane of the stomach and/or duodenum. Association analysis of common polymorphisms of matrix metalloproteinases genes MMP 1 (rs1799750, rs494379), MMP 2 (rs2285052), MMP 3 (rs3025058), MMP 9 (rs3918242, rs17576), and MMP 12 (rs2276109) and their tissue inhibitors TIMP 2 (rs8179090) and TIMP 3 (rs9619311) was carried out in 353 patients with a gastric ulcer or duodenal ulcer and in 325 unrelated healthy individuals from the Republic of Bashkortostan. Associations of polymorphic variants rs1799750 and rs494379 of gene MMP 1, rs3025058 of gene MMP 3, rs3918242 and rs17576 of gene MMP 9, and rs9619311 of gene TIMP 3 with the risk of peptic ulcer disease in Russians and Tatars were revealed.

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