The aim of study was to assess the feeding level on a commercial farm and to evaluate the effect of active dry yeast culture supplementation on blood indicators of dairy goats. Eighteen goats were divided into control and experimental groups. Beginning one week before expected kidding does in experimental group were supplemented 10 g/day/goat of yeast until 100d post-partum, after which the dose was increased to 20 g/day/goat. Blood samples were taken on days 7, 30, 80, 120 and 180 of lactation. There were differences in AST and ALT activity, and ALB, total protein, and creatinine contents between groups on the 180 th day of lactation. The parameters of lipid and bone profiles changed concurrently/in parallel in both groups and differences between the groups were found only in calcium and total protein contents at the end of the experiment. The level of creatinine kinase was higher than the upper limit of reference value in both groups. In the experimental group there were no differences in macroelement contents during lactation. In the control group the contents of most macroelements were lowest on 180 th day of lactation. Some biochemical indicators had values below references (glucose, AST, ALT GGT LDH, calcium, total protein), which means that the diet of the animals was not properly balanced or may be because of a malnutrition problem. However, the values in the experimental group underwent much lower fluctuations, and thus the yeast supplementation could have had a positive influence on the homeostasis and could have improved the intestinal absorption of minerals.