case required 3-4 weeks, another 5-6, and a third 12 weeks' continuous treatment before the sputum could be rendered mucoid and H. influenzae-negative. One case failed to respond.A total of 204 relapses were observed during 306 patient-months of intermittent antibacterial treatment. The majority were associated with reappearance of H. influenzae.In our view, the conclusion is inescapable that noncapsulated H. influenzae is responsible for keeping the chronic inflammatory process smouldering in bronchiectatic individuals.We are indebted to the Antibiotics Clinical Trials (Non- possibility of a direct relationship to the extent, duration, and severity of the lesion, and the effect of the remedial chemotherapy now available. In each case a complete quantitative analysis of all protein fractions has been made.Clinical Method A total of 327 adult patients with pulmonary tuberculosis were examined. They were selected without reference to their clinical condition, the first six attending each routine chest clinic session being invited to co-operate. To provide control values, 28 of the patients' adult "contacts," who were radiologically free from disease but living in a like domestic environment, were also examined. A clinical assessment was made of each patient at the time that the blood was withdrawn, and the erythrocyte sedimentation rate (Westergren) was also estimated. The assessment was made in relation to five main factors, recorded separately and uniformly for each patient, so that correlation with the biochemical findings was facilitated. These factors were:1. Extent of Disease.-The assessment was entirely radiological, based upon the zone system (Ministry of Health, 1947 Tubercle bacilli demonstrated in sputum or laryngeal swabbings, changing radiological shadows, or the presence of an obvious cavity were necessary, either alone or in combination, before a patient was classed as " active." Separate categories were also provided for "quiescent" and " arrested " cases (Ministry of Ilealth, 1947 The total protein concentration was measured by the specific-gravity method (Phillips et al., 1944). Electrophoresis was carried out on Whatman No. 1 filter paper at pH 8.6 in an M/010 barbitone buffer. By means of a glass slide 0.01 ml. of serum was applied to the paper strip. A potential of 105 volts was applied to the paper for 15-16 hours.The strips were then dried in an oven at 1200 C. for 30 minutes, and stained for 10 minutes in 0.2% lissamine

In the gaseous exchange reaction H2/HDO the catalyst (Pt/Charcoal) of concentration 0.4 gm Pt per 100 ml catalyst proved to be highly efficient. Its preparation is simple but precaution is needed to choose, optimum conditions in activating the charcoal prior to impregnation, the right grain size to reduce channelling, the proper reduction process and an efficient purification system to remove poisons. The regeneration of the catalyst is described. The kinetics and mechanism of this reaction are discussed.

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Ein Pt‐Aktivkohle‐Katalysator (0,4 g Pt/ 100 ml Kontakt) ist hochwirksam gegenüber der Hz/HDO‐Austauschreaktion.