Smoking is one of the risk factors in the disturbance development in the "mother-placenta-fetus" system which serves as one of the major preventable factors of pregnancy unsuccessful outcome for both mother and fetus. In order to identify characteristics of hemodynamic status of "mother-placenta-fetus" system in smoking pregnant women the analysis of physiological indicators of Doppler ultrasound had been done by means of the of uteroplacental, fetoplacental and fetal blood flow assessment. The study included 120 pregnant women of Northern Medical Clinical Center named after N. A. Semashko of Russian Federal Medical and Biological Agency at 30-34 weeks' gestation period (group of smokers - 80 people and non-smokers - 40 people); 85.0% of pregnant smokers have a slight degree of nicotine dependence, 5.0% - a moderate, and 10.0% - strong according to Fagerstrem's test; smoking history was 10,6 ± 3,9 years. Changes in the feto-placental blood flow predominate in the group of the pregnant smoking women. It is indicated by the systolic-diastolic ratio and resistance index, reflecting the kind of "brain protection effect of the fetus" and occurred in Doppler signs of increased blood flow in the middle cerebral fetal artery, against decrease of blood flow in the umbilical artery. The necessity is justified to spend additional Doppler study of utero-placental, feto-placental and fetal blood flow to identify compensatory changes in placenta blood vessels, umbilical cord and forecasting the development of hypoxia in the fetus of vascular origin, during the third ultrasound screening of smoking pregnant women.

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Tobacco smoking during pregnancy affects how the course of pregnancy and fetal development and subsequent child. The aim of this work was to create a model of survival probability prediction of smoking during pregnancy, aimed at finding appropriate approaches in the development of individual psycho-correctional program. Methods. In a cross-sectional study women living permanently in Arkhangelsk and the Arkhangelsk Region, in the III trimester of pregnancy were involved, who are hospitalized or ready to delivery in hospitals. On the basis of the psychological characteristics of the individual multiple regression analysis was applied. Results. Based on the regression coefficients and weighted odds ratios for each of the characteristic values it shows that the living conditions and the locus of control in the area of family relations are the most important features, and responsible for the continuation of smoking during pregnancy; further on the importance placed are an instinct of "freedom", a level of neuroticism and presence of the depressive type of psychological components of gestational dominants elements. Conclusion. The proposed model allows to predict the likelihood of continuation of smoking women based on their bio-psychosocial characteristics, to understand what is on the basis of chemical addiction, and to plan individual routes of medical and psychological assistance.

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