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The article reveals the factors of formation and consolidation of regional monopolies in modern conditions. Regional monopoly is considered as a special type of monopoly operating under conditions of objective constraints on supply and demand caused by the singularity of institutional environment. Assessment of institutional environment of regional monopolies is based on the application of Pattern integral method. The integral estimation is based on the following coefficients: density K PD, territoriality K T and service K S. This methodology allows us to assess the degree of institutional environment, to rank the set of regions in probability of occurrence of regional monopolies and to identify the factors that cause these monopolies. Evaluation of institutional environment of regional monopolies allows us to work out appropriate adjustment of economic policy in the region aimed at overcoming factors that predetermine regional monopolies.