Aim: The effect of photodynamic antimicrobial chemotherapy (PACT) on oral biofilms was evaluated. Methods: Biofilms formed in vitro were treated with sensitizer (S) and/or light (L) in the test (S⁺L⁺) and control (S^–L^–, S⁺L^–, S^–L⁺) groups. Additionally, 21 volunteers wore intraoral devices and the biofilms formed on each side of the device were referred to as S⁺L⁺ or S^–L^– groups. Results: Significant decreases in the viability of in vitro biofilms were observed after PACT. PACT was ineffective in inhibiting multi-species biofilms formed in situ. Conclusion: PACT was effective on in vitro biofilms and was ineffective on in situ biofilms.

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