Introduction: Blood transfusion saves millions of lives. Donors undergo certain stringent selection criteria to ensure safe and quality blood and blood products. During such process it is likely that donors may get deferred either temporarily or permanently. Deferral leads to precious loss of donors and blood units. Morever rates and reasons of deferral vary from region to region. The aim of the study was to analyse rates and reasons of donor deferral in our hospital. Material and Methods: It is a retrospective study done over a period of 6 years from January 2012 to December 2017. Details of donors who were deferred either temporarily or permanently during the study period was collected from the donor registry. Results: Out of the 15,807 donors who registered for blood donation during study period, 971 donors were deferred due to several reasons both temporarily and permanently. Total deferral rate of 6% as comparable to other studies in literature. Conclusion: Knowledge about rates and reasons of donor deferral may guide medical personnel to focus on donor screening. Proper follow up measures can be carried out in case of temporarily deferred donors to bring them back to donor pool.