Оригинальные исследования Конфликт интересов. Авторы заявляют об отсутствии конфликта интересов. Conflict of interest. The authors declare no conflict of interest. Финансирование. Работа выполнена при поддержке Министерства образования Республики Беларусь (договор с «МГЭИ им. Сахарова» БГУ № 05/20 от 17.02.2020 г.). Financing. The study was supported by the Ministry of Education of the Republic of Belarus (agreement No. 05/20 from 17/02/2020). Соответствие принципам этики. Исследование одобрено локальным этическим комитетом. Conformity with the principles of ethics. The study was approved by the local ethics committee.

The modern development and improvement of mathematical models that describe the radiobiology of processes in the body occurring under the influence of radiation every year lead to more complicated calculations related to the estimation of its impact both on the effectiveness of radiotherapy and on the possibility of making changes to the radiation treatment regimen. This significantly increases the time spent by medical physics and radiation oncologists and also requires special training of qualified specialists capable of performing such calculations. The aim of the study is to optimize calculations related to the estimation of radiation doses when the radiation treatment schedule changes, by modeling such changes with specially designed software on the basis of the theory of a linear-quadratic radiobiological model. The Web application is accessed via the Internet link https://hypo-calc.github.io/. As an example of using the Web application, the possible cases in clinical practice are considered.

The development of radiobiological models made it possible to mathematically describe biological phenomena in the body under the influence of radiation. The history of the development of radiobiological models began immediately after the discovery of X-rays and continues now, overcoming more and more restrictions. The practical application of radiobiological models is an integral part of clinical practice in cancer treatment.

No abstract

The quality of radiation treatment for oncological diseases can be influenced by a large number of factors. Among them, the breaks that occur during the course of radiotherapy play an important role. Split courses of radiotherapy are used in the practice of radiation treatment of head and neck cancer, as well as prostate cancer. Breaks between the stages of the course of radiotherapy lasting 1-2 weeks are carried out in elderly, debilitated patients or in the presence of radiation reactions of 3-4 degrees. Before the start of radiotherapy, a set of measures is taken to prevent radiation reactions. This can affect the fact that the course of radiotherapy will be carried out without interruption. Using Cox regression, it is proposed to evaluate the effect of interruptions in the course of radiotherapy on the outcome of treatment for head and neck tumors, as well as the prostate tumors taking into account the observation period.