No abstract

The global community is experiencing one of the largest infectious disease outbreaks in the 21st century. In the Saratov Region, the first case of new coronavirus infection was confirmed on March 19, 2020.The maximum increase in cases was noted between May 15 and June 30, during that time the total number of infected people in the region increased from 1526 to 6444. Since July 2020, a stable incidence level of new coronavirus infection has been observed in the Saratov Region, without a steady decline.The aim of the study was to assess the status of population immunity to the SARS-CoV-2 virus among residents of Saratov and the Saratov Region under the COVID-19 epidemic.Materials and methods. In the period from June 23 to July 26, 2020, a serological study of blood samples from 3372 volunteers of different age groups was conducted. The content of antibodies to SARS-CoV-2 was determined by ELISA using a set of reagents “ELISA anti-SARS-CoV-2 IgG” produced by the State Scientific Center of Applied Microbiology and Biotechnology of the Rospotrebnadzor (Russia).Results and discussion. In general, the incidence of COVID-19 in the Saratov Region is taking place against the background of moderate seroprevalence to the SARS-CoV-2 virus, accompanied by a high incidence of non-apparent (asymptomatic) forms of the infectious process. The absence of clinical symptoms of the disease, in the context of the limited use of methods for determining the RNA of the SARS-CoV-2 virus in PCR (11 % of the region’s population) makes it difficult to assess the real spread of the virus in the population and to establish the timing of the formation of persistent herd immunity. A low rate of antibody response among individuals with a positive result of PCR analysis, as well as among volunteers who had an infection in May, June 2020, indicates a weak formation of the immune response, or the prevalence of individuals reacting mainly by activating the cellular link of the immune system in the population. The obtained results, although they need to be explained in a number of respects, can be applied to the organization of preventive measures, including vaccination, in the region.

Presented are the results of ecological and epizootiological surveillance of the territory of the Saratov region, which was carried out in autumn of 2010. The surveillance was aimed at detection of West Nile (WN) virus circulation and premises for WN Fever natural focus formation. It is demonstrated that in 2010 WN virus circulation took place in damp biotopes of the Saratov region territory, and that common species of small mammals were involved in it. Presented are the results of analysis of the WN virus role in the infectious pathology in the territory of the Saratov region.

по материалам воз, от острых лихорадочных болезней в странах западной африки ежегодно погибают более 250 тыс. человек [10]. причем значительную долю в нозологической структуре регистрируемых лихорадок традиционно составляют малярия и брюшной тиф. указанные цифры, тем не менее, не отражают всей полноты конъюнктуры заболеваемости в западноафриканском регионе в связи с тем, что в качестве критериев постановки диагноза в боль-шинстве случаев используются только клинические данные [8]. с начала 2014 г. на фоне эпидемии болезни, вызванной вирусом эбола (бввэ), зарегистрированной на территории гвинейской республики, либерии и сьерра-леоне, и при привлечении международных ресурсов уровень лабораторной диагностики значительно повысился [2, 3]. но, несмотря на отработанную схему индикации отдельных возбудителей инфекционных болезней, часто регистрируются

Setup is database containing characteristics of variable tandem repeats, oligo-nucleotide primers and probes of the genomes of the strains bacterial and viral infections agents of the I-II pathogenicity groups. It allows for accumulation of information on genome regions. Using the incorporated VBA one can rapidly analyze the data and carry out substantiated calculation of gene-diagnostic preparations based on various PCR frameworks.