Intranasal administration of basic fibroblast growth factor prevented or reduced oligokinesia, muscular rigidity, and weight loss and also prevented mortality in mice with parkinsonism induced by repetitive intraperitoneal injections of 1-methyl-4-phenyl-l,2,3, 6-tetrahydropyridine. These beneficial effects are probably due to trophic actions of the factor, whereby the degeneration of nigrostriatal neurons is weakened and delayed and their survival is prolonged.

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The current status of knowledge about the roles played by radical reactions in the pathogenesis of cerebral pathologies is reviewed, and it is shown that these reactions are of key importance to the damage sustained by cellular structures of the central nervous system. Novel approaches to the management of cerebral disorders, based on the use of antioxidants, are considered.