E. V. Shilovskaya scite author profile

E. V. Shilovskaya

5Publications

21Citation Statements Received

10Citation Statements Given

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Affiliations

Ministry of Health of the Russian Federation, Kazan State Medical University

Publications

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Biopharmaceutical assessment of a polycomplex matrix system based on carbomer 940 and Eudragit® EPO for colon-specific drug delivery

et al. 2011

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The biopharmaceutical properties of a new drug carrier based on an interpolyelectrolyte complex (IPEC) between Carbomer 940 and Eudragit ® EPO have been studied in the form of a polycomplex matrix system (PMS) intended to be a potential carrier for peroral drug delivery systems. The release profiles of diclofenac sodium from the proposed PMS and Voltaren ® retard in model gastroitestial tract medium belong to the intestine-soluble and sustained-release types, respectively. Evaluation of the pharmacokinetic parameters of the PMS revealed a close in vitro/in vivo correlation. The proposed PMS, in contrast to the parent drug, provides targeted drug delivery to the colon region and is comparable with Voltaren ® retard with respect to the bioavailability and the main pharmacokinetic parameters.Key words: interpolyelectrolyte complex, Carbomer 940, Eudragit ® EPO, polycomplex matrix system (PMS), Voltaren ® retard, in vitro/in vivo correlation. 491 0091-150X/11/4508-0491

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Семина

Shilovskaya

Tarasova

et al. 2002

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Семина

Shilovskaya

Тихонова

et al. 2002

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Stereoselective synthesis and neurotropic activity of phosphorylacetic acid derivatives

et al. 2006

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Synthesis and pharmacological activity of (2-chloroethoxy-4′-dimethylaminophenyl)phosphorylacetic acid hydrazide (CAPAH) and its metabolite (N-acetyl derivative)

et al. 2013

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E. V. Shilovskaya

Biopharmaceutical assessment of a polycomplex matrix system based on carbomer 940 and Eudragit® EPO for colon-specific drug delivery

Untitled

Untitled

Stereoselective synthesis and neurotropic activity of phosphorylacetic acid derivatives

Synthesis and pharmacological activity of (2-chloroethoxy-4′-dimethylaminophenyl)phosphorylacetic acid hydrazide (CAPAH) and its metabolite (N-acetyl derivative)

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