Registration of Auditory Steady State Responses – ASSR test – is the main objective test, providing information about hearing thresholds at the basic speech frequencies (500–4000 Hz). One of the limitations for this test is the level of electroencephalographic (EEG) activity, corresponding to child’s the physiological sleep condition. However, compliance with this condition in diagnostics of hearing is not always possible in children with severe neurological and neuropsychiatric disorders.
Using canine model of chronic postinfarction myocardial ischemia we evaluated angiogenesis and cardiomyogenesis after combined revascularization by laser tunneling of the pericicatricial zone followed by implantation of bone marrow mononuclear cells into the channels. It was shown that the numerical density of arterioles and capillaries considerably increased 1 month after revascularization. We also observed a considerable increase in the density of cardiomyocyte nuclei in the test area, a 2-fold increase in the total area of nuclei, and an increase in the mean area of cardiomyocyte nuclei. The number of PNCA-positive cardiomyocytes significantly increased after combined revascularization. Our findings suggest that combined revascularization of the pericicatricial zone of the myocardium promoted angiogenesis and stimulates regeneration of cardiomyocytes.
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