The exposure to carbon disulfide of workers in charge of different jobs in a Belgian viscose plant was measured by means of personal monitoring of the inhaled air and by quantitative assay of 2-thio-thiazolidine-4-carboxylic acid (TTCA) in urine. It was found that the atmospheric carbon disulfide concentration varied considerably among different jobs, among different individuals doing the same jobs and for the same individuals in the course of the working period. The 2-thio-thiazolidine-4-carboxylic-acid levels increased markedly during the exposure. The correlation between individual personal monitoring results and the increase TTCA levels was found to be statistically significant.
Nocturnal polyuria (NP) is an important cause of nocturia and it is related to an imbalance in water and/or sodium homeostasis. Antidiuretic hormone (ADH) and atrial natriuretic peptide (ANP) are believed to play an important role in this excessive urine production overnight, however, many other hormones are involved. ADH and ANP are both directly and indirectly influenced by the renin-angiotensin-aldosterone system (RAAS), prostaglandins antagonize both ADH and RAAS and sex hormones have a predominantly antidiuretic effect by stimulating ADH and RAAS, meaning that any disturbance can lead to an imbalance in diuresis. Since nocturia is a condition affecting sleep, melatonin secretion can also be affected, leading to a decrease in the antidiuretic effect and to an increase of nocturnal urine production. Depending on the underlying condition affecting any of these hormones, a more specific therapeutic approach might lead to a restoration of the normal diuresis cycle and to a good night's sleep. The characteristics of each of these hormones, the pathophysiology in NP and the therapeutic implications are set out in this review.
A 26-year-old man collapsed in his home. His mother found him with "twitching limbs" and then "unconscious," and initiated chest compressions. On arrival of the emergency medical team, he was awake and oriented, with normal vital signs and blood sugar. There was no evidence of a tongue bite or urinary incontinence. An ECG taken in the emergency room revealed right bundle
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