Recent researches left no doubt in clinical efficacy of allogenic fibroblasts transplantation in case of burn treatment. There are several problems concerning indications and terms of transplantation performance of cell culture in treatment of boundary burns. The authors would like to prove an application of allogenic fibroblast culture in surgical treatment of victims with extensive dermal burns. The authors analyzed the results of surgical treatment of 36 miners, who were cured in burn department of V.K. Gusak Institute of Emergency and Plastic Surgery (Donetsk) at the period from 2004 to 2013. It was found that the application of fetal allogenic fibroblasts reduced the number of repeated autoplasty on 36% in main group of patients due to optimization of wound healing in case of burns.

The article studied an influence of operative treatment on miners in the stage of burn shock, complicated by multi- and combined trauma and how these treatment options have changed the lethality and burn complications rates. All data based on an analysis of retrospective research. A primary surgical treatment of burn wounds was performed using simultaneous grafting by temporary biological cover for superficial burns during the burn shock stage in the main group of patients. For miners of comparison group this strategy hasn’t been applied and they were operated after ending of burn shock. The rate of development of burn sepsis decreased in 3,2 times (p=0,0001), the frequency of pneumonia reduced in 2,91 times (p=0,0001) and toxic encephalopathy - in 1,7 times (p=0,004) in the main group in relation to the comparison group. The authors made a conclusion, that significant reduction of the rate of the most dangerous complications of burns allowed decrease of lethality in patients of main group in 2,6 times in relation to the comparison group. There wasn’t carried out the primary surgical treatment of burns with covering of postoperative wound surfaces by temporary biological material during burn shock stage in comparison group.

Abstract. Fetal fibroblast culture transplantation results were evaluated in the treatment of 18 burn victims. Comparison group consisted of 18 burn patients received medical care without cellular technologies utilization. The main comparison parameters in the study groups: the timing of the first stage of autodermoplasty; the number of autodermoplasties during the treatment; hospitalization duration; the newly formed epidermis area estimation. Fetal fibroblast culture transplantation in burn patients with extensive skin defects was performed on average 14,883,56 days after the injury. The timing of the first stage of autodermoplasty did not differ in the main and control groups, not exceeding an average of 19,122,01 days (p=0,48). An average of 2,710,67 surgeries using cell technologies performed in patients of the study group. The use of fetal fibroblasts culture in patients with extensive skin defects reduces the need for autodermoplasty by 1,6 times due to the granulation tissue formation and the epidermal growth beginning 7 days after and complete epidermal formation 14 days after transplantation. Regenerative medicine technologies utilization in patients with extensive skin lesions is possible and appropriate. Due to the fetal fibroblasts culture transplantation a kind of temporary biological coating is formed in the wound. It accelerates the wound healing process phase change from exudation to proliferation and the preparation of skin defects for autodermoplasty, expanding the possibilities of effective patients treatment.

В результате своевременного оперативного лечения и индивидуальной интенсивной терапии удалось спасти жизнь ребенку при менингококцемии и некрозе кожных покровов на площади 40 % поверхности тела. Многократное хирургическое лечение ран проводилось с использованием клеточных технологий. Это позволило добиться первичного приживления аутодермотрансплантатов при дефиците донорских ресурсов.