Technological progress has had negative effects as well as positive effects if it affects the life industry and the entire ecosystem significantly through the great consumption of natural resources, and here the construction sector in general and the health sector, in particular, have a role in this. From the perspective of keeping pace with technological development, responding to environmental changes, and paying attention to hospital environments (especially since the emergence of modern epidemics), and because the construction sector is the largest consumer of energy in the world, which made international organizations move towards creating a sustainable environment in the construction of hospital buildings by reducing energy consumption. This research focused on studying the components and principles of sustainable design for hospital buildings and the environmental, economic, health, and social benefits of sustainable development in the healthcare industry. In addition to the research objective, which is to build a model as a guide to guide health care officials interested in applying sustainable design principles in hospital design, to achieve an ideal sustainable hospital environment. To achieve this goal, a comprehensive theoretical framework was built by adopting a descriptive and analytical approach and extracting the most important vocabulary and effective indicators for sustainable design in hospitals.