The Total Synthesis of Lysergic Acid 3087 in the ultracentrifuge,8'41 as are polysaccharides generally.With respect to immunological homogeneity it has been established by several investigators that proteins which are non-homogeneous in the ultracentrifuge,42 electrophoretically4 3 and in amino acid composition31 may be immunochemically uniform.The relationship of amino acid composition to specificity among the blood group substances is not clear from the data presented. Work on the inhibition by oligosaccharides of the precipitation of blood group substances with specific antibody suggests that the carbohydrate presents binding sites for the immunological reaction.44 In view of the general similarity of amino acid composition, it is (41) R. A.

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The versatility of Raney nickel as a catalyst in effecting various reductive transformations of organic compounds is quite well known (1, 2). Catalytic oxidations in the presence of Raney nickel, however, are relatively obscure (2,11). Paul (3) and Palfrey (4), for example, have shown that certain secondary alcohols may be dehydrogenated catalytically to the corresponding ketones; however, temperatures up to 250°must be used, and even then yields leave much to be desired. A recent report (5) of work by H. Ruschig at the I. G. Farbenindustrie laboratories has described the catalytic conversion of pregnenolone (I) to pro-COCHs Z\ Axl/V' HO-CO CHS gesterone (II) in the presence of a special Raney nickel catalyst and cyclohexanone as a hydrogen acceptor. The object of the present investigation was to determine the generality of this oxidation and to study the possibility of using it in the reverse sense; i.e., as a reductive method in the presence of a hydrogen donor. The latter phase would constitute an extension of the work of Mozingo et al. ( 12).