¹ FCAV -Unesp Jaboticabal -andrelgalvao@hotmail.com ² FMV -Unesp Araçatuba RESUMO: Os protozoários do gênero Cryptosporidium sp. são parasitos que completam seu ciclo biológico na superfície de células epiteliais dos tratos respiratório, gastrointestinal e urinário de mamíferos, aves, répteis e peixes. A criptosporidiose é uma enfermidade que quando ocorre na forma de infecção natural, geralmente se apresenta assintomática ou com alterações gastrointestinais. Considerada uma zoonose, pois os animais quando infectados, principalmente os bovinos, constituem em fonte de infecção para o ambiente e para o homem, uma vez que eliminam grandes quantidades de oocistos em suas fezes. A sintomatologia quando presente é caracterizada por diarréia aquosa, desidratação, dores abdominais, perda de peso e morte, principalmente em indivíduos imunossuprimidos, e notadamente em paciente com vírus da imunodeficiência humana (HIV) e em crianças. Métodos terapêuticos eficazes no combate deste agente para os animais e para o homem, até o presente momento não foram estabelecidos, sendo aplicado o tratamento de suporte. Desta forma, trata-se de uma doença emergente, e a organização mundial de saúde a colocou na lista das doenças negligenciadas. Medidas de profilaxia são recomendadas como saneamento básico, utilização de métodos apropriados para a inativação dos oocistos e garantia de higiene pessoal constituem táticas para se minimizar a disseminação do Cryptosporidium. A presente revisão literária teve como objetivo descrever a importância da criptosporidiose em saúde pública. Palavras-chave: bovinos; cão; Cryptosporidium; gato IMPORTANCE OF CRYPTOSPORIDIOSIS AS ZOONOSIS ABSTRACT:The protozoa of the genus Cryptosporidium sp. are parasites that complete their life cycle on the surface of epithelial cells of the respiratory, gastrointestinal and urinary tracts of mammals, birds, reptiles and fish. Affected animals generally are asymptomatic but gastrointestinal disorders sometimes can be present. Criptoporidiosis is considered a zoonosis. Infected animals, especially cattle, are a source of infection for the environment and humans, because they eliminate large numbers of oocysts in their feces. The symptoms when present is characterized by watery diarrhea, dehydration, abdominal pain, weight loss and death, especially in immunosuppressed individuals, and especially in patients with human immunodeficiency virus (HIV) and children. Therapeutic methods effective to eliminate this agent in animals and humans has not been developed but it is necessary to applied support treatment. Criptosporidiosis is considered by the World Health Organization as an emerging disease. Basic sanitation, use of appropriate methods for the inactivation of oocysts and security of personal hygiene are recommended as Prophylactic methods to minimize the spread of Cryptosporidium. This literature review was aimed at describing the importance of cryptosporidiosis in public health.

The myxomatous mitral valve degeneration (DMVM) is the most common heart disease in dogs. The treatment of congestive heart failure (CHF) from DMVM is based on the use of angiotensin-converting enzyme inhibitors (ACE inhibitor) Receptor antagonists of angiotensin II (ARBs) promote complete blockade of angiotensin II, and are used in the treatment of CHF in humans, but is not common in dogs. The objective of this research was to compare the clinical responses of dogs carriers DMVM treated with enalapril-ACE inhibitors, losartan-ARBs. Thirteen dogs with DMVM and ICC class Ib were randomized into two groups as follows: G1-enalapril and G2-losartan. On physical examination, electrocardiogram and blood pressure were measured on days 0, 14, 28 and 56 after the begging of treatment. Radiographic measure, Vertebral Heart Size-VHS and ecodopplercardiográficas variables were obtained on days 0 and 56. Data were subjected to analysis of variance with repeated measures. There was no difference (P>0.05) for ecodopplercardiográficas, electrocardiographic and radiographic variables between the groups studied. In relation to time, there was a decrease (P <0.05) of the VHS, duration of the P wave and the QRS complex variables. We conclude that losartan acts similarly to enalapril in the initial treatment (first 56 days) of dogs with DMVM class Ib and II of the CHF.