Rev Rev Rev Rev Rev Bras Enferm, Brasília 200 Bras Enferm, Brasília 200 Bras Enferm, Brasília 200 Bras Enferm, Brasília 200 Bras Enferm, Brasília 2009 9 9 9 9 jan-fev; jan-fev; jan-fev; jan-fev; jan-fev; 6 6 6 6 62 2 2 2 2(((((1 1 1 1 1):):):):): 119-24 119-24 119-24 119-24 119-24.. .. . I I I I RESUMO RESUMO RESUMO RESUMO RESUMO A SIDA coloca questões sociais, humanitárias e jurídicas cruciais, e ameaça alterar seriamente fundamentos da estrutura social de tolerância e entendimento que sustém a vida das nossas sociedades. A partir de uma contextualização dos aspectos clínicos e epidemiológicos do VIH/SIDA, este artigo de revisão bibliográfica faz uma abordagem da vivência psicológica e das implicações da infecção com o Vírus da Imunodeficiência Humana Adquirida na mulher grávida. ABSTRACT ABSTRACT ABSTRACT ABSTRACT ABSTRACT AIDS raises a social issue, humanitarian, legal, and threatens to change the social structure founding of tolerance and understanding, that sustains the life of our societies. From a clinical and epidemiological background of HIV/AIDS, this article of literature review makes an approach about psychological experience and implication of the Human Immunodeficiency Virus infection in pregnant woman. Descriptors: Descriptors: Descriptors: Descriptors: Descriptors: HIV; AIDS; Women's health; Pregnancy. RESUMEN RESUMEN RESUMEN RESUMEN RESUMEN SIDA plantea cuestiones sociales, humanitarias y jurídicas fundamentales, y amenaza cambiar gravemente motivos de la estructura social de tolerancia y comprensión, que sustenta la vida de nuestra sociedad. Desde una contextualización de los aspectos clínico y epidemiológicos del VIH / SIDA, en este artículo de revisión bibliográfica se hace un enfoque acerca de la v psicológica y la implicación de la infección por el Virus de Inmunodeficiencia Humana Adquirida en la mujer embarazada. Cor Cor Cor Cor Correspondência: respondência: respondência: respondência: respondência: Sílvia do Rosário Piteira Natário de Lourenço. Rua Dr. José Brás, 16, 1º Distrito CEP 2910-559. Setúbal, Portugal. 120 120 120 120 120 Rev Bras Enferm, Brasília 200 Rev Bras Enferm, Brasília 200 Rev Bras Enferm, Brasília 200 Rev Bras Enferm, Brasília 200 Rev Bras Enferm, Brasília 2009 9 9 9 9 jan-fev jan-fev jan-fev jan-fev jan-fev; 6 ; 6 ; 6 ; 6 ; 62 2 2 2 2(((((1 1 1

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FLOT regimen became the standard perioperative treatment in several centers around the world for esophagogastric tumors despite concerns about toxicity. In addition, FLOT has never been compared with other docetaxel-based regimens. To address this question, we conducted a systematic review of PubMed, Embase and Web of Science including prospective or retrospective studies of docetaxel based perioperative regimen in gastric and esophagogastric tumors. Data regarding chemotherapy regimens, efficacy and toxicity were extracted. Outcomes were compared using a random effects model. Of 548 abstracts, 16 were considered eligible. Comparing the studies with meta-analysis we can see that the regimens are similar in terms of pathological complete response, resection rate, progression free survival and overall survival in one year, without significant heterogeneity. The meta-regression of docetaxel dose failed to show any association with dose ranging between 120–450 mg/m². Regarding the toxicity of the regimens it is noted that the regimens are quite toxic (up to 50–70% of grade 3–4 neutropenia). The results of this meta-analysis with a combined sample size of more than 1,000 patients suggest that docetaxel perioperative regimens are equivalent in outcomes. Prospective trials addressing modified regimens should be performed to provide less toxic strategies and be applicable to all patients.