A pulsed Nd:YAG laser approved for clinical use in Russian Federation was used for laparoscopic partial nephrectomy(LPN). Patients with Ɍ 1 N 0 M 0 (N=17) cancer underwent laser LPN during 2006-2009 for removal tumor sized from 2.0 to 3.9 cm. Successful laser LPN was performed without ischemia in all cases. Bleeding during laser LPN was substantially reduced due to laser coagulation of tissue. Currently all patients are under medical supervision with no recurrence of tumor. A pulsed Nd:YAG laser showed safety and efficacy of LPN in humans.