OBJECTIVETo evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) in type 2 diabetic patients with GFR >60 mL/min/1.73 m2.RESEARCH DESIGN AND METHODSThis was a cross-sectional study including 105 type 2 diabetic patients. GFR was measured by 51Cr-EDTA method and estimated by the MDRD and CKD-EPI equations. Serum creatinine was measured by the traceable Jaffe method. Bland-Altman plots were used. Bias, accuracy (P30), and precision were evaluated.RESULTSThe mean age of patients was 57 ± 8 years; 53 (50%) were men and 90 (86%) were white. Forty-six (44%) patients had microalbuminuria, and 14 (13%) had macroalbuminuria. 51Cr-EDTA GFR was 103 ± 23, CKD-EPI GFR was 83 ± 15, and MDRD-GFR was 78 ± 17 mL/min/1.73 m2 (P < 0.001). Accuracy (95% CI) was 67% (58–74) for CKD-EPI and 64% (56–75) for MDRD. Precision was 21 and 22, respectively.CONCLUSIONSThe CKD-EPI and MDRD equations pronouncedly underestimated GFR in type 2 diabetic patients.

The CKD-EPI equation is less accurate in patients with Type 2 diabetes when compared with healthy individuals, with a 2.5-fold greater bias.

RESUMO Objetivo: Investigar os efeitos da atuação na linha de frente da COVID-19 na saúde mental de profissionais de hospital público. Métodos: Análise transversal de entrevistas de ingresso em estudo prospectivo, com abordagem mista, em hospital da rede pública no Sul do Brasil. Resultados: Foram entrevistadas 123 pessoas, 76% profissionais de enfermagem e 81% mulheres. Escore igual ou superior a sete pontos no Self-Reporting Questionnaire (SRQ-20) foi obtido para 40% da amostra, 45% tiveram escore igual ou superior a 25 pontos na Perceived Stress Scale (PSS) e 41% atingiram escores compatíveis com burnout no Inventário de Burnout de Oldenburg (OBI). Os desfechos estiveram associados entre si (p < 0,05), mas nenhuma associação foi verificada com as variáveis independentes. Nas entrevistas em profundidade, foram destacados como dificuldades: longos plantões sem intervalos, bem como paramentação, pressão e cansaço maiores que os habituais, isolamento no próprio hospital, risco da própria contaminação e temores e culpa relacionados às famílias. A união da equipe apareceu como aspecto que favorece o desempenho no enfrentamento dessa situação. Conclusões: Profissionais apresentam quadro de sofrimento psicossocial. Recomenda-se priorizar repouso e intervalos, o que poderá exigir adequações de rotinas e espaços físicos, além de ampliar a oferta de apoio emocional às equipes.

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CKD-EPI reduces GFR underestimation in individuals with GFRs >60, but still presents a quite low accuracy at this GFR range. Moreover, it tends to overestimate GFR in subjects with GFRs <60 mL/min/1.73 m2. CKD stages 1 and 2, diabetes and young age had a negative influence on the performance of the equations.