No abstract

Plamenac P, Nikulin A, Pikula B. Cytology of the respiratory tract in former smokers. Acta Cytol 1972;16:256-60. Schreiber H, Bibbo M, Wied GL, Saccomanno G, Nettesheim P. Bronchial metaplasia as a benign or premalignant lesion. Altogether 26 lesions were induced in 13 patients, whereas none occurred in the controls (p <0 001). Sutures caused most of the lesions (15), and those so induced had a mean maximum diameter of 2-3 mm and lasted for an average of four days. Ulcers induced mechanically were clinically indistinguishable from those usually seen in the patients, except that they were generally smaller and healed more quickly.These findings confirm that mechanically induced injury of the oral mucosa may cause ulceration in people susceptible to aphthous stomatitis. Such a procedure may therefore be helpful in identifying subsets of patients.

No abstract

A double-blind trial of a tetracycline suspension was carried out in 25 patients with recurrent aphthous oral ulcerations. A combined topical-systemic treatment procedure was used. Both the placebo and tetracycline groups experienced reductions in ulcer incidence during the treatment period, whereas only the tetracycline group showed significant reductions in ulcer duration, size, and pain. Tetracycline treatment apparently alters the severity of the ulcer, but does not appear to affect those factors responsible for recurrences. The side effects recorded in patients taking tetracycline were comparable to those in patients on placebo.