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Acknowledgements: EFSA and the authors of this Editorial wish to thank all the programme affiliates (i.e. chairpersons, speakers, moderators, panellists, rapporteurs) and participants of the 'ONE -Health, Environment & Society -Conference 2022' for their most valuable contributions to the event. This Editorial builds on presentations given, discussions held and comments made during the event, as well as on the conference proceedings prepared by Devos et al. (2022). We also wish to thank the ECDC, ECHA, EEA, EFSA, EMA and JRC colleagues, as well as the members of the External and EU Member States Advisory Boards (see https://www.one2022.eu/programme/ scientific-programme-committee) who helped us to co-shape the scientific programme of the conference.