association between improved QoL at initial approval and open-label studies (OR 3.85; p¼0.053). Improved OS in the PMP was associated with immunotherapy (OR 8.20; p¼0.026) and drugs with companion diagnostics (OR 11.67; p¼0.006). Improved QoL in PMP was associated with sample size (OR 0.73; p¼0.031), immunotherapy (OR 9.14; p¼0.02) and open-label studies (OR 8.89; p¼0.048).
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