Background: Papillary lesions of the breast are a heterogeneous group of breast lesions that are difficult to diagnose as benign or malignant. These lesions have varied morphologic features that carry differing prognostic implications for affected patients. Accurate diagnosis is required to ensure that effective treatment is achieved. Papillary lesions can have increased risk of carcinoma and recurrence, in these patients even for lesions yielding a benign concordant diagnosis of papilloma at percutaneous biopsy, surgical excision may be warranted. Malignant lesions are usually surgically treated. Depending on stage-adjuvant chemotherapy and/or radiation therapy is given.Methods: A retrospective study was conducted at Shaukat Khanum Memorial hospital and Research Centre Lahore Pakistan. We reviewed the electronic records of diagnostic and registered patients from January 2007 till December 2017 in women imaging section, in age range of 25 to 75 years. Total 150 diagnosed patients with benign or malignant breast papillary lesions were selected and their conventional breast imaging (mammography and ultrasound) and histopathology was retrospectively analyzed on SPSS.Results: Patients were predominantly asymptomatic or on follow-up to an abnormal mammogram. Of the 150 cases most of the patients had intra-ductal papilloma followed by invasive papillary carcinoma and intra cystic papillary carcinoma. Few patients had intra-ductal papillomatosis and invasive micro papillary carcinoma.Conclusions: Conventional breast imaging remains the first main stay and quite sensitive in detecting breast papillary lesions leading to early detection and management.

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Background & Objective: Renal tumors are a common finding in diagnostic imaging; these lesions usually are solid or cystic, benign or malignant, and the correct diagnosis may be difficult. The current study aims at to determine the diagnostic accuracy of magnetic resonance imaging for the diagnosis of Wilms tumor taking histopathology as gold standard. Methodology: This cross-sectional study was carried at the Department of Radiology, The Children’s Hospital & Institute of Child Health Lahore over 6 months from March 2019 to September 2019. The study involved 125 children of both genders aged between 2 years to 14 years presenting with a neoplastic mass in the retroperitoneum on ultrasound abdomen during initial workup. These children were assessed on MRI for the diagnosis of Wilms tumor. Later the diagnosis was confirmed on histopathology which was taken as gold standard and the diagnosis of MRI was judged accordingly as true/false and positive/negative. A written informed consent was obtained from every patient. Results: The mean age of the children was 5.8±3.9 years having a male predominance with male to female ratio of 1.8:1. Wilms tumor was suspected in 13 (10.4%) children on MRI. The diagnosis of Wilms tumor was confirmed in 13 (10.4%) children on histopathology. MRI was found to be 76.9% sensitive, 97.3% specific and 95.2% accurate with positive and negative predictive values of 76.9% and 97.3% respectively. Conclusion: In the present study, MRI was found to be 95.2% accurate in the differential diagnosis of Wilms tumor in children presenting with retroperitoneal mass which along with its non-invasive and radiation free nature advocates the preferred use of MRI in the diagnostic evaluation of such children in future oncologic practice. Keywords: Retroperitoneal Tumor, Wilms Tumor, MRI, Diagnostic Accuracy

Objectives: To determine the accuracy of ultrasound in diagnosing biliary atresiataking histopathology as gold standard. Design: Cross Sectional Study. Settings: Departmentof Diagnostic Radiology and Gastroenterology at Children’s Hospital and Institute of ChildHealth, Lahore. Period: Over 1 year from 13-01-2015 to 12-02-2016. Material and Methods:This study involved 210 infants aged between 2-6 weeks referred from outpatient departmentand emergency of gastroenterology department with suspicion of biliary atresia. Ultrasoundof all these cases was carried out and biliary atresia was labeled on a positive triangular cordsign. Core needle biopsy sample was taken from the liver adjacent to the porta hepatis andhistopathological examination was done. Results of histopathology were taken as gold standardand results of ultrasonography were judged accordingly as true positive or false positive. Awritten informed consent was taken from each patient. A predesigned proforma was used torecord patient’s demographic details along with ultrasound and histopathological diagnosis.Results: The mean age of the patients was 4.31±1.22 weeks. There were 109 (51.9%) maleand 101 (48.1%) female patients with a male to female ratio of 1.1:1. Ultrasound was found97.5% sensitive, 87.7% specific and 95.2% accurate with positive and negative predictive valueof 96.31% and 91.5%, respectively. Conclusion: Ultrasound was found extremely sensitive toolfor the diagnosis of biliary atresia. Its non-invasive nature and lack of radiation exposure furthermake it ideal for pre-operative diagnosis in suspected cases in future practice.