Objective Previous observational studies suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients. Methods We analysed several cardiac markers in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardized mean difference (SMD) with 95% confidence intervals. Results Twenty nine clinical studies were included in this meta-analysis. This study found significantly higher CKMB (0.64, 95% CI = 0.19-1.09,), PCT (0.47, 95% CI = 0.26-0.68), NT-proBNP (1.90, 95% CI = 1.63-2.17), BNP (1.86, 95% CI = 1.63-2.09), and D-dimer (1.30, 95% CI = 0.91-1.69) in severe compared to non-severe COVID-19. This study also found significantly higher CKMB (3.84, 95% CI = 0.62-7.05), PCT (1.49, 95% CI = 0.86-2.13), NT-proBNP (4.66, 95% CI = 2.42-6.91,), BNP (1.96, 95% CI = 0.78-3.14), troponin (1.64 (95% CI = 0.83-2.45), and D-dimer (2.72, 95% CI = 2.14-3.29) in death cases compared to survived cases with COVID-19. Conclusions In conclusion, high CKMB, PCT, NT-proBNP, BNP, and D-dimer could be predictive markers for the severity of COVID-19, while high CKMB, PCT, NT-proBNP, BNP, troponin, and D-dimer could be predictive markers for the survival of COVID-19 patients.

BACKGROUND: Sleep deprivation is strongly associated with cardiovascular disease (CVD) via sympathetic overstimulation and systemic inflammation in general population. However, the significance of poor sleep quality in chronic kidney disease (CKD) is still underexplored.METHODS: This study assessed the sleep quality of 39 with non-dialysis CKD (ND CKD) patients and 25 hemodialysis CKD (HD CKD) patients using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Poor sleeper was defined as individual with PSQI > 5.RESULTS: The prevalence of poor sleeper (30% vs. 60%, p=0.029) and the cummulative PSQI (ND CKD 4.5±4.4, HD CKD 8±6, p=0.038) are different between ND CKD and HD CKD groups. Among the ND CKD, there are association between short sleep duration (< 5 hours per day) with elevated diastolic blood pressure groups (r=0.421, p<0.05); habitual sleep efficiency with platelet-to-lymphocyte ratio (r= 0.532, p<0.0001); daytime dysfunction with increased hs-CRP (r=0.345, p=0.032) and neutrophil-to-lymphocyte ratio (r=0.320, p=0.046). In HD CKD group, a requirement to use sleep medication was associated with elevated highsensitivity C-reactive protein (hs-CRP) level (r=0.434, p=0.030) and decreased monocyte-to-lymphocyte ratio (r=- 0.410, p=0.042); daytime dysfunction was associated with serum hs-CRP (r=0.452, p=0.023).CONCLUSION: This study revealed that some features of poor sleep quality in CKD patients including low sleep efficiency, daytime dysfunction and requirement to use sleep medication were associated with increased diastolic blood pressure, hs-CRP and blood-count-based inflammatory predictors. Thus, this finding prompt to pay closer attention to sleep complaints in the management of CVD risk factors in CKD patients.KEYWORDS: sleep quality, chronic kidney disease, blood pressure, inflammation

The stipulation of the covid-19 virus as a global pandemic has resulted in massive changes in all aspects of life for the world community. The increasing number of cases of covid-19 transmission accompanied by an increasingly significant number of deaths has an impact on the imposition of social distancing or physical distancing in a number of countries. This has led to changes in the order of life of the Indonesian people, especially the socioeconomic conditions of the Indonesian people which have experienced a lot of decline, so that it requires efforts to empower them. PRA (Participatory Rural Appraisal) is an approach to community empowerment that involves active community participation. It's just that, during the Covid-19 Pandemic, PRA experienced problems in its implementation because of the physical distancing policy. Therefore, this paper will explain the actualization of PRA during the Covid-19 pandemic. This paper originates from a qualitative research conducted in Karanglo Village, Klaten Regency, Central Java. The method of data collection is done by using the method of observation, interviews, and document studies using data triangulation techniques as a method of data validity. This research focuses on: (1) Implementation of the PRA approach in the empowerment process of the Karanglo village community during the Covid-19 pandemic, (2) The results of the identification of problems and potentials of the Karanglo village community originating from the PRA process carried out, (3) Opportunities and challenges of implementing PRA during the Covid-19 pandemic.

All of the listed companies must obedient to the regulation of Indonesian stock exchange about good corporate governance, but actually there are still many violations. This study aims to analyze the obdience of listing companies against regulation about good corporate governance and explain effect of factorsin in influencing obdience. The analysis method used in this study is descriptive statistic analysis.The population in this study is 21 mining companies listed in Indonesian stock exchange in the period 2012-2014. The result showed that factors that affect the obdience of listing companies in applying good corporate governance is age, size, frequency of meeting the board of commisioners, corporate secretary, public share ownership, and timely financial statement reporting. While the factor composition of board of commissioner, number of audit committee, frequency of meeting the audit committee and CSR does not affect.

Inclusive children or children with special needs are those who have abnormalities in the process of growth or development; which can be physical, mental-intellectual, social, or emotional. The World Health Organization predicts that around 7% of the world's total children population is inclusive children. Exercise that are adapted and modified according to their needs, the type of abnormality and the ability of inclusive children are able to improve motor and sensory abilities so that they will improve their quality of life. The purpose of this activity is to increase the knowledge and skills of parents with inclusive children in implementing adaptive exercise for their children. The method used was seminar and training. Activity evaluation was carried out using questionnaire to observe the increase of knowledge. This activity was attended by 31 parents and 31 inclusive children, with the highest parents’ age range in 31-40 years, which is mothers 38.7%; 41.9% father. The age of expecting mothers of inclusive children mostly ranges from 31-40 years (35.5%). Increased knowledge about child development was 31% (pretest 68, posttest 91.8) and increased knowledge about adaptive sports was 72.18% (pretest 49.6, posttest 85.4).abstrakAnak Berkebutuhan Khusus (ABK) adalah anak yang dalam proses pertumbuhan atau perkembangannya mengalami kelainan atau penyimpangan; yang bisa berupa fisik, mental-intelektual, sosial, atau emosionalnya. Organisasi kesehatan dunia memprediksi sekitar 7% dari keseluruhan populasi anak dunia merupakan ABK. Olahraga yang diadaptasi dan dimodifikas sesuai dengan kebutuhan, jenis kelainan dan tingkat kemampuan ABK mampu memperbaiki kemampuan motoris dan sensoris sehingga akan meningkatkan kualitas hidupnya. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan dan ketrampilan orang tua ABK dalam melatih olahraga adaptif buat anak-anaknya. Metode yang digunakan adalah seminar dan pelatihan. Evaluasi keberhasilan kegiatan dilakukan dengan kuesioner untuk melihat peningkatan pengetahuan. Kegiatan dihadiri oleh 31 orang tua dan 31 ABK, dengan rentang usia orang tua terbanyak di 31-40 tahun yaitu ibu 38,7%; ayah 41,9%. Usia ibu mengandung ABK terbanyak di rentang 31-40 tahun (35,5%).  Peningkatan pengetahuan pada materi tumbuh kembang anak sebesar 31% (pretest 68, posttest 91,8) dan peningkatan pengetahuan materi olahraga adaptif sebesar 72,18% (pretest 49,6, posttest 85,4).