Scabies has become a major public health problem, especially in low resource settings. In this area no previous study regarding scabies prevalence and associated risk factors have been conducted. Therefore, this study was carried. The aim of this study to provide data on the position of scabies with regard to prevalence and the factors related to it and to recommended measures for prevention and control of infestation. A cross-sectional study carried out over a period of 6 months from 1 January to 30 June 2022 in dermatology outpatient clinic of two main teaching hospitals Al-Gamhoria and Al-Wahda, in Aden Government. Out of total of 2575 patients examined, 90 had scabies (3.4%) with highest prevalence rate in children aged 8- 15 years (27.8%). The infection was higher in males than females (57.8 % vs 42.2 %). The present study concludes that poor socio-economic conditions, such as illiteracy, overcrowding and sharing room, joblessness have a statistically significant relation with scabies. In addition, to family history of itchy skin lesions.