Aortic stiffness measurements were found abnormal in patients with psoriasis. We have also demonstrated that there were significant correlations between aortic stiffness parameters and disease duration. This study suggests that aortic stiffness measurement could be used for assessment of cardiovascular risk in psoriasis patients, and that only continuous long-term disease control may be helpful in reducing the cardiovascular risk associated with psoriasis.

The results of this study show that narrow-band UVB treatment causes a detectable chromosome damaging effect.

PUVA describes the treatment of patients with psoralens plus an exposure to a source of UV light of 320-400 nm (UVA). Contradictory results have been reported on the chromosomal damage of PUVA when assayed by sister chromatid exchange (SCE) method. Micronucleus (MN) test is used to detect both clastogenic (breaking) and aneugenic (abnormal segregation) effect of physical/chemical agents on the chromosomes. No data have been found on the MN formation in the cells of PUVA treated patients. Frequency of micronuclei in 72 hours cultivated/mitogen-stimulated lymphocytes of patients have been evaluated at zero time and after 20, 40, 60 sessions of PUVA treatment. While the beginning MN frequency was approximately 0.22% (n=23), it raised to approximately 0.32 (n=23), approximately 0.42 (n=14) and approximately 0.53% (n=10) corresponding respectively to 20, 40 and 60 sessions. These sessions correspond reciprocally to 54+/-23, 172+/-48, 300+/-61 joules/cm2 of UVA and 13, 26, 39 mg/kg of 8-metoxypsoralen (8-MOP). While large interindividual variances were apparent, highly significant differences have been observed between initial MN frequency and after that of the 20, 40 and 60 sessions, (p = 0.000, p = 0.004, p = 0.005, reciprocally, Wilcoxon two-related samples test). The coefficient of correlation between MN frequency and UVA doses starting from zero to 60 sessions of treatment has been found as r = 0.61. This indicates a significant relationship between UVA doses and MN frequencies. However, MN inducibility and synergistic property of 8-MOP with UVA should be taken into account. Gradual MN increase during different sessions of PUVA treatment shows that--once appeared--a part of MN at least persist in the cells of patients from a few days to a few weeks. Smoking as a confounding factor seems to increase MN frequency (p = 0.053, Mann-Whitney U-test) in the beginning population, taken as the control population. This is the first report on the kinetics of MN formation during different sessions of PUVA treatment. Based on our results, we concluded that PUVA treatment causes a detectable chromosome damaging effect on the relatively profound cells/tissues of its human users. Therapists should be careful with its use, especially on the patients who may be more susceptible to carcinogenesis (e.g. immunosuppressed and/or elderly subjects).

No abstract

ÖzetEozinofilik pannikülit subkutan dokuda daha çok eozinofillerin oluşturduğu mikst tipte iltihabi hücre infiltrasyonu ile seyreden bir pannikülittir. Etiyolojide en sık gnathostomiyazis (Larva migrans profondus), lökositoklastik vaskülit ve eritema nodosum suçlanmaktadır. Burada steroid tedavisine yanıt alınamayan ancak dapson tedavisi ile tam olarak düzelen idiyopatik eozinofilik pannikülitli bir olgu sunularak literatür bilgileri gözden geçirilmiştir. (Turk J Dermatol 2010; 4: 94-6 GiriEozinofilik pannikülit, subkutan ya dokusunun yo un olarak eozinofillerden olu an infiltrasyonudur. Klinik olarak genellikle eritemli subkutan nodüller eklinde kar mza ç kmaktad r. Baz hastal klarla birliktelik bildirilmektedir (1). Burada, altta yatan herhangi bir neden tespit edilemeyen ve dapson tedavisine yan t al nan bir olgu literatür bulgular e li inde sunulmaktad r. OlguElli ya nda erkek hasta, be y ld r y lda bir kaç kez tekrarlayan kol ve bacaklarda k zar kl k, i lik ikâyetiyle klini imize ba vurdu. i likler yakla k 20 gün devam edip kendili inden geçiyormu . Dermatolojik muayenesinde; sa kol, sol uyluk ve bacakta eritemli 5-6 cm çap nda nodüler lezyonlar tespit edildi ( ekil 1).Al nan deri biyopsisinde yüzeysel dermiste perivasküler mononükleer hücre infiltrasyonu, subkutan ya doku içerisinde nodüler ve lobüler yer yer septal yerleim gösteren bask n olarak eozinofilleri ayr ca nötrofil ve histiyositleri de içeren mikst tipte iltihabi hücre infiltrasyonu izlendi ( ekil 2). Bulgular eozinofilik pannikülit ile uyumlu olarak de erlendirildi.Hastan n tam kan say m nda hemoglobin: 16.8 g/dl, beyaz küre: 6530 hcr/ L, trombosit: 175.000 /L, kan biyokimyas nda üre: 23.5 mg/dl, kreatinin: 0.9 mg/dl,