Abstract:Moringa Oleifera leaves were screened for its toxicological effect and some pharmacological activities in broiler chicken. Toxicological effect was studied using upgrading oral doses of 75% ethanolic extract in different groups of mice with monitoring the toxicological symptoms and mortality rate. The anti-coccidal activity of Moringa Oleifera powdered leaves for prevention and its 75% ethanolic extract for treatment of coccidiosis were studied in broilers. The obtained result proved that there were no toxicological symptoms or mortalities obtained till oral administration of 6000 mg/kg b. wt. Inclusion of Moringa olifera powder (0.5 and 1%) to broiler's feed were very efficacious and equal to diclazuril (1ppm) in preventing symptoms of coccidiosis associated with experimental infection with mixed Eimeria species. The anti-coccidal activity of Moringa Oleifera powdered leaves and its 75% ethanolic extract were studied on one-day old chicks. The experimental infected chicks with mixed Eimeria species induced severe coccidiosis in non medicated chicks and led to high mortality reached to (26.76%). Addition of 200 and 400ppm of Moringa Oleifera ethanolic extract induced marked curative effect of cocci diosis manifested by reduced mortality percent and improved PM lesion to be 13.3 and 10% respectively compared to 13.3% for group treated with the reference drug (25ppm) toltrazuril.