Introduction: Cerebral aneurysm coiling considers ideal treatment for intracranial aneurysms. Objective: to evaluate the effect of nursing interventions protocol on patients' clinical outcomes undergoing peri cerebral aneurysm coiling. Materials and methods: Quasi-experimental study conducted at the Neuro-psychiatry Center affiliated to Tanta University. A Convenience sample of 60 adult patients undergoing peri cerebral aneurysm coiling for the first time. Four tools used Tool I Patients Structured interview schedule. Tool II Glasgow Coma Scale. Tool III Numerical rating scale. Tool IV: Post aneurysmal patient assessment tools. Results: The present study shows that less than half of both study and control group age ranged from 41-60 years, also it shows that more than half of study group and approximately two third of control group were female. In addition, it reveals that there was improvement of post aneurysmal coiling nursing interventions protocol mean results which include that majority of study group post nursing interventions protocol and minority of control group post routine hospital care haven’t localized pain and neck stiffness, furthermore all patients of study group and less than two third of control group haven’t localized hematoma, Moreover majority of study group and less than one quarter of control group haven’t aneurysmal nausea.