Abstract. The present study aimed to investigate morphology structure, blood structure and the rheological properties, (viscosity, torque, shear stress and shear rate), of mice blood serum at wide range of shear rates after whole body exposed to different ultraviolet doses. Eighty healthy male mice were used in this study. A significant increase in the mice blood serum viscosity occurs after irradiated by the ultraviolet C radiation (UVC). The relationship between viscosity and shear rate exhibited a non-Newtonian behavior for all mice group. The relationship between shear stress and % torque and shear rate exhibited a linear behavior for the control and UVC irradiated mice group. The mice blood serum showed a non-significant change in the UVC irradiated mice % torque and shear stress with shear rates (40-500 s -1 ) compared with the control. There was a noticeable change in the general behavior movement with a significant effect in blood mice structure after exposure to UVC radiation.