Objectives: The present study aimed to investigate the effect of acceptance and commitment therapy (ACT) on the quality of life of infertile women during the treatment. Materials and Methods: This study was a randomized clinical trial that was conducted on 40 infertile women admitted to the clinics of Arak, Iran. They were selected through a convenience sampling technique and were randomly assigned to intervention (n=20) and control (n=20) groups. The Fertility Quality of Life (FertiQoL) Questionnaire was used as a data collection tool, which was completed before and one month after the intervention. The counseling group was provided with eleven 90-minute sessions of ACT twice a week. Then, the data were analyzed using SPSS 23 through the chi-square test and independent samples test. Results: Based on the results, there was a statistically significant difference between the mean scores of the quality of life in ACT and control groups before and one month after the intervention (P<0.05). Conclusions: In general, it seems that ACT improves the infertile women’s quality of life and this treatment can be used for alleviating the quality of life of these women taking into account the high incidence of infertility.