Objective: To investigate the predictive factors for amputations in southern Brazil. Methods: This was a review of medical records from amputated patients in a tertiary hospital in southern Brazil. Results: One hundred and fifteen medical reports regarding to admissions of 51 amputated patients (31.37% women and 68.62% men) were analyzed. The main cause of amputation in diabetics was the neuropathy and its complications. Among nondiabetics, the main causes of amputation were polydactyly (31.58%) and traumatism (traffic accidents, home accidents, and work accidents). This data showed that the investigated amputations are predominantly in male, aging approximately sixty years old, presenting comorbidities like diabetes and arterial hypertension. Moreover, the most amputations were performed as the minor type. Conclusion: These data can contribute for implementation of targeted health education strategies and interventions, improving the prevention of amputations in persons with diabetes.