The pilot study was conducted in one of the Sultanate of Oman’s government universities. In an isolated case, the researchers conducted one whole course only using a flipped classroom set-up for an entire semester. Advanced lectures were given in the form of short videos and reading materials to the students. Class time was spent for follow up, assessment and reinforcement of learning and was conducted by giving classroom activities ranging from group work, self-assessment exercises, case studies, muddiest point assessment etc. The study revealed five explanatory variables to flipped classroom effectiveness and through focus group discussions, the common learning challenges faced by the students were also determined.