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Several authors have observed that methylxanthines derivatives could increase. the duration of activity of ejaculated human spermatozoa (Glezerman et al. -1978; Haesungshartm and Chulavatnatal -1973; Hicks et al. -1972;Schoenfeld et al. -1975; Turner et al. -1978). In previous studies (Aparicio et al. -1980) it was showed that Pentoxifylline, a methylxanthine derivate (Popendiker et al. -1971) with a longer lasting effect and a higher hydrosolubility than other agents of the group, could also improve, by in vitro incorporation, the duration activity of ejaculated spermatozoa of normal men (Aparicio et al. -1980).

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