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person-to-person contact via the faecal-oral route, the sanitation Objectives: A systematic review was conducted to improve understanding of the epidemiology of hepatitis A and E viruses (HAV,HEV), to investigate HAV and HEV viral outbreaks and to describe the distribution and magnitude of all cases in the Mediterranean region countries during the period 2006-2017.Study Design: Not all study design types were included. Single case reports were not included unless the case was reported as the primary infection of the outbreak. This systematic review combined both experimental and non-experimental studies from 2006 onwards. Experts' opinions and qualitative studies were excluded.Methods: Four databases (Scopus, PubMed, ISI Web of Science Core Correlation and SpringerLink electronic journal) were searched from 2006 to July 2017. Totally, 31 hepatitis A and Ε viral outbreaks in the Mediterranean region were identified. Most of the reported outbreaks were in European region, followed by South Mediterranean countries.