Traditional therapy and extensive use of medications and intravaginal autolymphocyte therapy show different results of the treatment of vulvovaginal infections. The purpose of the article was to explore safe and highly effective methods to treat vulvovaginal infections and diseases of the pelvic organs. The standard clinical and laboratory screening of 70 patients of reproductive age was carried out to diagnose the diseases of the reproductive tract. The screening included the description of quantitative and qualitative characteristics of vaginal discharge, examining the mucous covering of the vulva and vagina, microscopic examination of Gram-stained vaginal swabs, endocervical cultures, and diagnosis of sexually transmitted infections using polymerase chain reaction. Intravaginal autolymphocyte therapy was used together with traditionally-accepted treatment schemes (etiotropic antibacterial and antifungal therapy) in the treatment of the main group (40 patients). Traditional treatment methods depending on the etiology of the development of infection were used in the control group (30 patients). The IgM, IgA, and IgG levels were also observed because of the possibility of causing embryo rejection. This study shows that in case of relapsing vulvovaginitis and mixed infections accompanied by disorders of the immune system at different levels, the use of intravaginal autolymphocyte therapy in a comprehensive therapy can be assessed as advisable and pathogenetically substantiated.

This study reports an assessment of adaptive possibilities of the central nervous system (CNS) in infants. The study shows how the homocysteine level depends on the severity of neurological deficit (ND) in infants, and how the serum homocysteine level changes during the various treatment regimens. (International Journal of Biomedicine. 2017;7(4):286-288.)

Aim: Application of a new method -intravaginal auto lymphocyte therapy in treatment of female infertility. Place and Duration of Study: I.M. Sechenov, First Moscow State Medical University, the study was performed in 2010. Results: A case report concerning treatment of a female patient with infertility by use of a new method of intravaginal administration of auto lymphocytes is presented. To prepare the patient to infertility treatment with help of intravaginal fertilization (IVF), 5 performances of intravaginal auto lymphocyte therapy were made. A pregnancy resulted simultaneously after the treatment course and finished by operative childbirth. Conclusion:In the case presented here the method of intravaginal auto lymphocyte therapy demonstrated its efficiency in treatment of infertility. We hope that in immediate future this method will provide us with a possibility to improve female infertility treatment results.

The purpose of our study was to evaluate the effectiveness of sodium deoxyribonucleate (Derinat, solution for intramuscular injection) in combination with standard therapy in the treatment of COPD Group C patients in outpatient settings. Materials and Methods: The study included 80 patients (43 men and 37 women) with COPD (Group C), mean age of 51.7±1.4 years. Blood sampling for the study was carried out 3 times-before the start of therapy, and on days 5 and 15. Using monoclonal antibodies, we determined the number of lyphocytes carrying markers CD3+, CD+, CD8+, and CD72+. The quality of life (QL) indicators were evaluated using the St. George's Respiratory Questionnaire (SGRQ). For at least 15 days, patients received standard COPD therapy. All patients were divided into 2 groups: Group 1 included 41 patients who received Derinat 75 mg intramuscularly once daily for 5 days; then-5 injections with an interval of 48 hours against the background of standard therapy. Group 2 included 39 patients who continued to receive standard COPD therapy. Results: The inclusion of Derinat in the complex therapy of COPD contributed to the normalization of the T-cell to B-cell ratio, an increase in the number of T suppressors. Assessing the clinical effects of combination therapy with the inclusion of the studied drug, a marked decrease in shortness of breath, cough, and the amount of sputum excreted can be noted in comparison with standard therapy. The improvement of the immunological status and clinical indicators against the background of complex therapy was accompanied by an increase in QL.

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