Background: miR-21 is overexpressed in many human cancers, including glioblastoma. Results: Insulin-like growth factor (IGF)-binding protein-3 (IGFBP3) is a novel miR-21 target gene and inhibits gliomagenesis in vitro and in vivo. Conclusion: miR-21 down-regulates IGFBP3, which acts as a tumor suppressor in human glioblastoma. Significance: IGFBP3 may have promise as a therapeutic target and prognostic marker for glioblastoma.

Diagnostic study, level III.

Background: miR-21 is overexpressed in many human cancers. Results: FBXO11 (a member of the F-box subfamily lacking a distinct unifying domain) is a novel miR-21 target gene, and inhibits tumorigenesis. Conclusion: miR-21 down-regulates FBXO11 which acts as a tumor suppressor in melanoma, prostate cancer and glioblastoma. Significance: FBXO11 may have promise as a therapeutic target, and as a diagnostic and prognostic marker in cancer.

No abstract