Introduction: The association between maternal plasma levels of neutrophil gelatinase-associated lipocalin (NGAL) and maternal complications in women admitted with severe early-onset preeclampsia was evaluated. Material and Methods: Plasma levels of NGAL were measured at admission in patients with severe early-onset (presenting before 34 weeks) preeclampsia. The maternal outcome of women with elevated plasma levels was compared with those with normal levels. Maternal complications included eclampsia, HELLP syndrome, acute renal failure, subcapsular hepatic hematoma, pulmonary edema and disseminated intravascular disease. Results: Sixty-seven patients were included. The median NGAL plasma levels in the group of women who subsequently had a complication were significantly higher than in those uncomplicated cases (114.8 vs. 84.2 ng/ml; Mann-Whitney U test p = 0.03). Maternal complications were more common in the elevated (>100 ng/ml) NGAL group (58.3 vs. 25.6%; χ² test p = 0.008), with an OR of 4.1 (95% CI 1.4-11.8). After adjustment by gestational age at onset, the association between elevated NGAL plasma levels and maternal complications remained significant (OR 4.2; 95% CI 1.4-12.4). Discussion: Women with severe early-onset preeclampsia are at higher risk of maternal complications if plasma levels of NGAL are elevated.

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Poster abstracts conventional 2DUS, 99% considers the former easier to interpret and with more emotional impact. -Maternal attitudes towards 3/4DUS were related to some maternal clinical, social and demographic variables. Conclusions: Most of the women in our study were satisfied with their experiences of 3/4DUS. Maternal attitudes towards 3/4DUS were related to maternal age, educational level, employment, pregnancy plannification, previous adverse perinatal outcome, parity, assisted conception pregnancies, gestational age, invasive prenatal testing and physician's expertise P09.17 Detecting fetal growth restriction by humerus volume using three-dimensional ultrasound Prenatal diagnosis of fetal growth restriction (FGR) is very important, as FGR may have increased risks with perinatal morbidity and mortality. Fetal humerus dysplasia is associated with a variety of congenital syndromes and FGR. For the assessment of the efficacy of fetal humerus volume in predicting FGR, we undertook a prospective, cross-sectional study using quantitative three-dimensional (3D) ultrasound (US). In total, 42 fetuses with FGR and 258 fetuses without FGR were included for the humerus volume assessment in utero by 3D US. All the fetuses were singletons and were followed up to delivery to determine whether they were complicated with FGR or not. Our results revealed that fetal humerus volume assessed by 3D US can differentiate fetuses with FGR from fetuses without FGR well. The best predicting threshold for FGR is at the 10th percentile by humerus volume. Using the 10th percentile as the cut-off, the sensitivity of fetal humerus volume in predicting FGR was 97.6%, specificity 87.2%, positive predictive value 55.4%, negative predictive value 99.6% and accuracy 88.7%. In conclusion, fetal humerus volume assessed by quantitative 3D US can be used to predict FGR prenatally. We believe fetal humerus volume assessment by 3D US would be a useful test in detecting fetuses with FGR. P09.18Psychological impact of three-dimensional fetal sonography University Hospital of Geneva, SwitzerlandObjective: The aim of this study was to evaluate the emotional impact of 3D ultrasound images of the fetus during the third trimester of pregnancy and to compare the understanding and satisfaction of parents after 2D and 3D examination. Method: A total of 40 primigravida couples (80 parents) with a single pregnancy and without any psychiatric history were included in this study after the second (2D) trimester scan. All parents accepted to participate to the study and had a 3D ultrasound at 28 weeks of pregnancy. The stress level was evaluated after 2D and 3D sonography with a standard questionnaire (EIS). Anxiety before and after the 28 weeks 3D scan was also measured with another questionnaire (STAI). Understanding of the 2D and 3D fetal images and satisfaction of the parents were evaluated at 20 and 28 weeks. Parents were also asked to complete a questionnaire during the postpartum period. Results: The overall response rate was 98% (39/40) for mothers. Anxiet...