Despite the large range of ready-made medicines, the extemporal formulation has not lost its significance. One of the most significant extemporal dosage forms in providing, including emergency medical care, is solutions for injection, which have technological features of manufacturing. The article presents the results of a study of the main properties of water during lowfrequency acoustic treatment for the preparation of stable saline solutions. Methods of stabilization of solutions for injection were studied. The effect of low-frequency acoustic treatment on the physical and chemical properties of osmotic water has been experimentally confirmed. Using computed quantum and chemical modeling, the most probable forms of water nanoclusters formed during low-frequency acoustic treatment are determined. Prospects of using the low-frequency acoustic treatment in the Pharmaceutical Industry and pharmacies to stabilize saline solutions for injection are shown. Further research will be related to the treatment of real physiological solutions of drugs with different molecular weights.

The studies were carried out in the Kirov region on sod-podzolic sandy loam soil in a long-time stationary experiment established in 1976. The article provides data (2010-2017) on four fallow-grain-grass crop rotations with various types of fallows, annual and perennial legumes (25-50 %), intercrops (12.5-37.5 %). The purpose of the studies is to compare the influence of some biologization techniques in eight-field crop rotations on the change in soil fertility and the balance of nutritional elements of sod-podzolic sandy loam soil. It is found that the application of low doses of mineral fertilizers (N30P30K30) and various types of green manure crops per rotation has significantly increased the content of mobile phosphorus in the arable soil layer (by 39-46 mg/kg). According to grouping the provision of soils with phosphorus, the content of this element passed into the «high provision» group. The content of exchangeable potassium in the soil remained in the «increased» provision group. In the control crop rotation with clean fallow at a minimum supply of nutrients with mineral fertilizers and root-stubble residues, the balance of nitrogen, phosphorus and potassium was created negative at the intensity of less than 100 %. The replacement of clean fallow for cropped and green manure fallows, as well as the introduction of intermediate cruciferous crops into the crop rotation structure contributed to the positive balance of nitrogen (250.2-484.3 kg/ha) with the intensity of 124-150 %. The biologization factors used in crop rotations favored the creation of a positive phosphorus balance (12.5-148.1 kg/ha) with the optimal intensity of 117-163 % and a positive potassium balance (128.9-395.8 kg/ha) with the intensity above the optimal value of 116-148 %. The most advantageous in terms of productivity and ensuring a positive balance of nutritional elements is crop rotation with two green manure fallows and sowing of stubble and hay cruciferous crops in three fields.

The manual is intended for students of the Faculty of Dentistry, residents, practicing dentists of various specialties. Dedicated to current issues of laser dentistry. Developed taking into account world scientific and clinical practice, experimental, laboratory and clinical data obtained by the authors. This manual presents materials relating to modern ideas about the use of laser technology in dentistry, highlights modern methods of diagnosis and treatment, clinical cases are given.

In this paper, we consider the control of animal carcasses and the detection of such a disease as scrapie. For our country, this animal disease remains quite rare, but at the same time it should not be overlooked. This is due to the fact that there are regular purchases of breeding cattle from abroad, and this is a risk of importing an infected animal. The relevance of the work is that the disease of sheep and goats-scrapie can not be detected at very early stages of its development. Symptomatic manifestations do not appear immediately, there are no clear clinical characteristics, which is why this disease can not be diagnosed for a long time. To assess the health status and predict the quality of products obtained, new approaches are needed to study the products of sheep and goat slaughter. Great importance is given to standard methods of studying, identifying certain patterns in clinical, anamnestic, morphological, metric and anatomical indicators of the animal body. Using these indicators and changing their dynamic characteristics, it is possible to make significant adjustments in the definition of this disease, which would allow us to develop a number of rules for modern veterinary and sanitary evaluation of animal slaughter products.