Background: Dentophobia can reduce the number of regular visits to dentists and endanger the oral health of people. New technologies such as virtual reality (VR) can be used in the treatment of psychological problems such as dentophobia. Objectives: The present study aimed to investigate the effectiveness of virtual reality exposure therapy (VRET) on dentophobia in clients of dental offices in the cities of Isfahan, Tehran, and Shahrekord in 2020. Methods: The research method was quasi-experimental with a pre-test, post-test, and follow-up design and a control group. The statistical population of this study consisted of all clients with dentophobia visiting private dental clinics of Isfahan, Tehran, and Shahrekord in 2020. Thirty clients with dentophobia who were willing to participate in the research were selected as the sample using convenience sampling and randomly divided into experimental and control groups (n = 15 per group). The experimental group underwent eight sessions (15-minutes sessions per week) of virtual reality exposure therapy, while the control group received no intervention. The follow-up was performed after 45 days. The research instruments included the Modified Dental Anxiety Scale (MDAS), Samsung Gear 360 (2017 Edition), and HTC VIVE Pro Virtual Reality Headset. Data were analyzed using repeated-measures ANOVA. Results: The results showed that virtual reality exposure therapy effectively decreased dentophobia in clients of dental offices in the experimental group (P = 0.0001). Conclusions: According to research findings, virtual reality exposure therapy was an efficient therapy for improving dentophobia and reducing phobia symptoms in clients of dental offices.
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