Programme Hospitalier Recherche Clinique, Institut Pasteur, Inserm, French Public Health Agency.

Assistance Publique-Hôpitaux de Paris and the University of Geneva.

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Among women with vaginal delivery who received prophylactic oxytocin, the use of tranexamic acid did not result in a rate of postpartum hemorrhage of at least 500 ml that was significantly lower than the rate with placebo. (Funded by the French Ministry of Health; TRAAP ClinicalTrials.gov number, NCT02302456 .).