LND was the only independent prognostic predictor of OS and DFS in patients with pN+ laryngeal SCC. Moreover, patients with LND ≥0.09 were significantly associated with high risk of regional recurrence. Thus, patients with LND ≥0.09 are at high risk of regional recurrence and death and may be considered for adjuvant chemoradiation.

The treatment of laryngeal squamous cell carcinoma (SCC) is based on proper design of therapeutic strategies aimed to control cervical lymph node metastasis. Cervical nodal metastasis is one of the most important prognostic factors in carcinoma of the larynx. [1] The incidence of clinically detectable lymph node metastasis in laryngeal carcinoma is high, and the levels II, III, and IV are the most commonly involved lymphatic groups in carcinoma of the larynx.