O objetivo deste trabalho foi analisar o perfil doloroso na coluna vertebral em estudantes universitários. Trata-se de uma pesquisa de campo analítica, do tipo transversal com abordagem quantitativa de 46 acadêmicos de universidades de um município do Maranhão. Foi aplicado um questionário sócio demográfico e avaliação física (QSDAF), para análise da ocorrência de sintomas dolorosos na região da coluna, decorrente ou não de atividade física. A intensidade da dor foi medida por meio da escala visual analógica de dor (EVA). A amostra contou com participantes de ambos os sexos, 56% dos avaliados relataram sentir dor somente ao repouso e não relataram dor ao praticar exercícios, 67% relatam sentir dor em 3 regiões, 62,28% dos participantes da pesquisa não realizavam nenhuma atividade física, a área com maior predominância de dor foi a lombar e a intensidade da dor variou de moderado à intenso. A maioria dos acadêmicos sentem dor em repouso sem associação a exercício nas três regiões da coluna vertebral, poucos acadêmicos realizavam alguma atividade física.
Euterpe oleracea (açaí) fruit has approximately 15% pulp, which is partly edible and commercialized, and 85% seeds. Although açaí seeds are rich in catechins—polyphenolic compounds with antioxidant, anti-inflammatory, and antitumor effects—almost 935,000 tons/year of seeds are discarded as industrial waste. This work evaluated the antitumor properties of E. oleracea in vitro and in vivo in a solid Ehrlich tumor in mice. The seed extract presented 86.26 ± 0.189 mg of catechin/g of extract. The palm and pulp extracts did not exhibit in vitro antitumor activity, while the fruit and seed extracts showed cytotoxic effects on the LNCaP prostate cancer cell line, inducing mitochondrial and nuclear alterations. Oral treatments were performed daily at 100, 200, and 400 mg/kg of E. oleracea seed extract. The tumor development and histology were evaluated, along with immunological and toxicological parameters. Treatment at 400 mg/kg reduced the tumor size, nuclear pleomorphism, and mitosis figures, increasing tumor necrosis. Treated groups showed cellularity of lymphoid organs comparable to the untreated group, suggesting less infiltration in the lymph node and spleen and preservation of the bone marrow. The highest doses reduced IL-6 and induced IFN-γ, suggesting antitumor and immunomodulatory effects. Thus, açaí seeds can be an important source of compounds with antitumor and immunoprotective properties.
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