The plant material was collected and prepared by aqueous decoction. The phytochemical study of extracts resulted firstly by characterizing secondary metabolites revealed by the tests of phytochemical screening and secondly by the assay by the method flavonoids aluminum trichloride. Animal material (rats and female mice) was prepared for the pharmacological study. The reducing activity of the free radical 2,2-diphenyl-1-picrylhydrazine extracts, the acute toxicity limits tests on female mice and determination of anti-inflammatory activity in vivo extracts taken along the induction method edema by carrageenin in female rats. The tannins and flavonoids were revealed in the aqueous extracts. The contents of Alchornea cordifolia and Mangifera indica Flavonoids are 241 and 194 mg equivalent of catechin respectively. The CE 50 extracts showed an antioxidant (0.02 mg/ml and 0.03 mg/ml) relatively low compared to the ascorbic acid with an CE 50 of 0.003 50 mg/ml. The safety of aqueous extracts of Alchornea cordifolia and Mangifera indica is demonstrated for DL 50> 5000 mg/ ml. The anti-inflammatory test with 500 mg/kg and 1000 mg/kg of extracts confirmed the inhibitory power of the extracts on inflammatory mediators : histamine, 5-hydroxytryptamine, kinins and prostaglandins. Conclusion and application of the Results:The rich aqueous extracts of Alchornea cordifolia and Mangifera indica polyphenolic constituents capable of trapping free radicals and increasing venous tone, also prevent the formation of mediators that cause inflammation.