Background and Aims: INTERCheckWEB is one of the most outstanding digital technologies, that could be implemented at the hospital level, supporting the clinicians in the evaluation of the therapy appropriateness, reducing the potentially inappropriate prescriptions, for the improvement of the clinical decision-making process. The paper aims at investigating the relationship between clinicians' behaviors towards digital decision support system in therapy appropriateness for elderly patients in polytherapy in medical departments, defining the factors that could influence clinicians to use INTERCheckWEB, for supporting drugs' prescription. Methods: A questionnaire was administered to 70 clinicians referring to Internal Medicine wards, of four Italian hospitals. The authors assessed how perceived usefulness, perceived ease of use, image, and output quality, would affect INTERCheckWeb intention to use. Inferential statistics, by means of a regression analysis, were conducted to define the main aspects useful to understand the factors impacting on such digital technology adoption in clinical practice. Results:The regression analysis reported that image, perceived ease of use and perceived usefulness, as well as the moderator effect of the voluntary use between the perceived usefulness and the intention to use, are the factors that most influence the use of INTERCheckWEB (adjusted R 2 = 0.870).Conclusions: Results demonstrated that clinicians would use INTERCheckWEB, when available, to identify all the information on situations that could be dangerous for the patients, thus limiting the drug-drug interactions, optimizing the overall patient's clinical pathway. Furthermore, the implementation of INTERCheckWEB could also contribute to the proper management of COVID-19 patients, since both hospitalized and symptomatic COVID-19 patients are frequently older, with comorbidities.

Background: INTERCheckWEB is one of the most outstanding IT innovative technology that can be implemented at hospital level, supporting the clinicians in the evaluation of the therapy appropriateness for a patient, specially reducing the potentially inappropriate prescriptions for elderly patients in polytherapy. The present paper aims at investigating the relationship between physicians and support decision system in therapy appropriateness for elderly patients in polytherapy, in order to is to assess the factors that can foster or hamper physicians in using INTERCheckWEB for drug prescription.Methods: A qualitative questionnaire based on a model broadly addressed in literature (Technology Acceptance Model – TAM2), was administered to seventy clinicians referring to Internal Medicine wards, of four Italian medium size hospitals. Based on TAM2, authors assess how perceived usefulness, perceived ease of use, image and output quality, affect INTERCheckWeb intention to use. Inferential analyses were conducted to define the main aspects useful to understand the factors impacting on INTERCheckWeb adoption in clinical practice.Results: The regression analysis reported that image, perceived ease of use and perceived usefulness, as well as the moderator effect of the voluntary use between the perceived usefulness and the intention to use, are the factors that most influenced the use of INTERCheckWEB (Adjusted R2 = 0.870).Conclusions: The analysis has demonstrated that clinicians would effectively use INTERCheckWEB, when available, to identify all the information that could be dangerous for the patient, choosing the proper drug and preventing potential interactions and medical errors.