No abstract

Cloud computing has been a hot topic in the research community since 2007. In cloud computing the online services are conducted to be pay as you use. Services need not to be in a long term contract with service providers. Service level agreements (SLAs) are agreements signed between a service provider and other party like a service consumer, broker agent, or monitoring agent. Because cloud computing is recent technology providing many services for critical business applications, the need for reliable and flexible mechanisms to manage online contracts is very important. This paper presents the main criteria which should be considered at the stage of designing SLA in cloud computing. Also, we investigate the negotiation strategies between cloud provider and cloud consumer and propose our method to maintain the trust and reliability between each party which is involved in the negotiation processes.

Environmental and genetic risk factors contribute to Parkinson’s Disease (PD) pathogenesis and the associated midbrain dopamine (mDA) neuron loss. Here, we identify early PD pathogenic events by developing methodology that utilizes recent innovations in human pluripotent stem cells (hPSC) and chemical sensors of HSP90-incorporating chaperome networks. We show that events triggered by PD-related genetic or toxic stimuli alter the neuronal proteome, thereby altering the stress-specific chaperome networks, which produce changes detected by chemical sensors. Through this method we identify STAT3 and NF-κB signaling activation as examples of genetic stress, and phospho-tyrosine hydroxylase (TH) activation as an example of toxic stress-induced pathways in PD neurons. Importantly, pharmacological inhibition of the stress chaperome network reversed abnormal phospho-STAT3 signaling and phospho-TH-related dopamine levels and rescued PD neuron viability. The use of chemical sensors of chaperome networks on hPSC-derived lineages may present a general strategy to identify molecular events associated with neurodegenerative diseases.

As therapeutic options and supportive care for the treatment of neoplastic disease have improved, there has been an associated increase in the incidence of leptomeningeal disease. In this review, the clinical presentation, natural history, diagnostic evaluation, and treatment options for this often devastating sequela of solid tumors, lymphoma, and leukemia will be summarized. The therapeutic efficacy of ionizing radiation, systemic agents, and intrathecal drugs will be examined from the existing literature. Additionally the pathophysiology, which in part defines the therapeutic limitations in approaching this patient population, will be discussed in order to assist in individualized clinical decision making.

Wireless Sensor Networks (WSN), an element of pervasive computing, are presently being used on a large scale to monitor real-time environmental status. However these sensors operate under extreme energy constraints and are designed by keeping an application in mind. Designing a new wireless sensor node is extremely challenging task and involves assessing a number of different parameters required by the target application, which includes range, antenna type, target technology, components, memory, storage, power, life time, security, computational capability, communication technology, power, size, programming interface and applications. This paper analyses commercially (and research prototypes) available wireless sensor nodes based on these parameters and outlines research directions in this area.