Calcium triflate has been identified as an efficient catalyst for the cycloaddition of nitrones to donor-acceptor cyclopropanes. The reaction proceeds with good to excellent yields of the corresponding tetrahydro-1,2-oxazines with high levels of diastereoselectivity. The generality of the reaction allowed for the synthesis of tetrahydro-1,2-oxazines bearing alkyl, aryl, and heteroaromatic substitution.
We conducted an investigation on the efficacy of service-learning in large environmental biology classes. We were interested in whether or not service-learning in classes with over 200 students has an impact on content learning, and attitudes/behaviors related to the content. Students completed a pre-survey, a service project, and reflection paper (experimental group), and a post-survey. Comparing pre-and post-surveys, student responses to attitude, and behavior questions revealed a positive impact on environmental worldview. Student confidence in understanding course content improved in the specific areas related to service projects. Overall, our study shows that large classroom learning is enhanced by short-term servicelearning projects.
Children with Lyme meningitis are often treated with intravenous ceftriaxone, although oral doxycycline may be effective. Parents were surveyed after observing a video describing a hypothetical Lyme meningitis treatment trial. Eighty-four of 102 (82%) would consent to their child participating. Parents would accept 2 additional days of symptoms (noninferiority margin) with doxycycline even if ceftriaxone hastened symptom resolution.
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